免疫介在性壊死性ミオパチー
免疫介在性壊死性ミオパチーとは、自己免疫反応により筋肉が障害される希少な筋炎です。急激な筋力低下、嚥下障害、呼吸困難などの症状がみられます。これらの症状が現れた場合は、膠原病科または神経内科を受診しましょう。
虎の門病院分院 腎臓内科
大庭 悠貴 監修
(参考文献)
Tanboon J et al. Classification of idiopathic inflammatory myopathies: pathology perspectives. Curr Opin Neurol. 2019, 32, 704-14.Watanabe Y. et al. Clinical features and prognosis in anti-SRP and anti-HMGCR necrotising myopathy. J Nephrol Neurosurg Psychiatry. 2016, 87, 1038-44.Suzuki S. et al. Integrated Diagnosis Project for Inflammatory Myopathies: An association between autoantibodies and muscle pathology. Autoimmun Rev. 2017, 16, 693-700.Allenbach Y, et al. Necrosis in anti-SRP+ and anti-HMGCR+myopathies: Role of autoantibodies and complement. Neurology. 2018, 90, e507-17.Pinal-Fernandez I, et al. Longitudinal Course of Disease in a Large Cohort of Myositis Patients With Autoantibodies Recognizing the Signal Recognition Particle. Arthritis Care Res. 2017, 69, 263-270
.Kassardjian CD, et al. Clinical Features and Treatment Outcomes of Necrotizing Autoimmune Myopathy. JAMA Neurol. 2015, 72, 996-1003.Oddis CV, Aggarwal R. Treatment in myositis. Treatment in myositis. Nat Rev Rheumatol. 2018, 14, 279-89
.Valiyil R, et al. Rituximab therapy for myopathy associated with anti-signal recognition particle antibodies: a case series. Arthritis Care Res. 2010, 62, 1328-34..Allenbach Y, et al. 224th ENMC International Workshop:: Clinico-sero-pathological classification of immune-mediated necrotizing myopathies Zandvoort, The Netherlands, 14-16 October 2016. Neuromuscul Disord. 2018, 28, 87-99.Habers GE, et al. Safety and efficacy of exercise training in patients with an idiopathic inflammatory myopathy--a systematic review. Rheumatology (Oxford). 2011, 50, 2113-24.Alemo Munters L, et al. Improvement in health and possible reduction in disease activity using endurance exercise in patients with established polymyositis and dermatomyositis: a multicenter randomized controlled trial with a 1-year open extension followup. Arthritis Care Res (Hoboken). 2013, 65, 1959-68.Boehler JF, et al. Effect of endurance exercise on microRNAs in myositis skeletal muscle-A randomized controlled study. PLoS One. 2017, 12, e0183292.Zhao Y, et al. Factors associated with refractory autoimmune necrotizing myopathy with anti-signal recognition particle antibodies. Orphanet J Rare Dis. 2020, 15, 181.Lim J, et al. Seronegative patients form a distinctive subgroup of immune-mediated necrotizing myopathy. Neurol Neuroimmunol Neuroinflamm. 2018, 6, e513.
初めての方へ
ユビー病気のQ&Aとは?
現役の医師が、患者さんの気になることや治療方法について解説しています。ご自身だけでは対処することがむずかしい具体的な対応方法や知識などを知ることができます。
病気・症状から探す医師・医療機関の方はコチラ